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Tag for aggressive bowel cancer

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UK scientists say they have found a marker for aggressive bowel cancers needing the most treatment.

Patients most likely to develop a more virulent strain of the disease could be pinpointed by a test which looks for a marker protein called Lamin A.
These patients should be given chemotherapy in addition to standard surgery to improve survival, the Durham University/NESCI scientists say.
Their work is published in the scientific journal PLoS ONE.
The team now aims to develop a Lamin A-based detection test for use in the health service.
Bowel cancer is the third most common cancer in the UK. Each year more than 36,000 people are diagnosed with the disease.
Almost three quarters of cases occur in people aged 65 and over. Chemotherapy is rarely used in their treatment as it could cause more harm than benefit in patients who are elderly and frail.
However, for the most aggressive cancers, chemotherapy can be a big help.
The scientists studied tissue samples from 700 bowel cancer patients and tracked their progress.
The patients who had the stem cell marker protein Lamin A present in their tissue were more likely to have an aggressive form of the disease.
The findings suggests that around one third of these patients will express the Lamin A stem cell marker and should be considered for chemotherapy.
Study co-author Professor Chris Hutchison, of Durham University and North East England Stem Cell Institute, said: "Currently the hospitals use a standard test to work out how far the cancer has progressed and then they use this to determine the treatment the patient should receive

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